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The effects of Ro 15-1788, a benzodiazepine antagonist with some agonist properties, were studied on adenosine and adenosine 5'-N-ethyl-carboxamide (NECA)-evoked depressions of rat cerebral cortical neuronal activity. Iontophoretically applied Ro 15-1788 had both antagonistic and potentiative interactions with adenosine. Reductions in the magnitude of… (More)
The actions of the p-chloroderivative of diazepam, Ro 5-4864 on the spontaneous discharges of rat cerebral cortical neurons and its interactions with depressions evoked by adenosine and adenosine 5'-N-ethylcarboxamide (NECA) were observed. Iontophoretically applied Ro 5-4864 had variable actions on cortical neuronal activity, exciting some neurons and… (More)