R. E. Nikkels

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Vasculitis is a rare complication of propylthiouracil therapy. Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders. We report detection of ANCA against human neutrophil elastase, proteinase 3, and myeloperoxidase in serum from six patients who developed evidence of vasculitis during(More)
A randomized controlled study covering a two-year pre-treatment and a five-year post-treatment period was performed in 42 patients with diabetic retinopathy given photocoagulation treatment in one eye. Patients with progressive diabetic retinopathy of equal intensity in both eyes were selected from a single diabetes department. The course of diabetic(More)
A case of duodenal somatostatinoma is described in a patient with Von Recklinghausen neurofibromatosis. The patient presented with exocrine pancreatic insufficiency, probably due to distal obstruction of the pancreatic duct by the tumor. Preoperative evaluation with calcium-pentagastrin and tolbutamide stimulation tests were nondiagnostic. At laparotomy,(More)
The antiarrhythmic drug, amiodarone, induces thyroid dysfunction, which is potentially dangerous in cardiac patients. After discontinuation of the drug it takes several months before euthyroidism is restored. The potent antithyroid drug, potassium perchlorate (KClO4), is used successfully to treat amiodarone-induced thyrotoxicosis, but it is less well known(More)
The case history of a 31-year-old woman is described. She had a history of thrombosis; in the past there had been an arterial embolus of the left superficial femoral artery and venous thrombosis of the right leg. The patient was admitted to hospital because of fever of unknown origin. During the hospital stay the diagnosis of probable SLE was made. She died(More)
Tissue Oxygenation in Severe Diabetic Ketoacidosis. K.G.M.M. Alberti, J . Darley, Pauline M. Emerson and T. D.R. Hockaday. Radcliffe Infirmary, Oxford. Tissue oxygenation has not been studied in diabetic coma, yet may be an impor tant factor in recovery. In 51 subjects in diabetic ketotic coma we have determined [lactate]/ [pyruvate] (L/P) and(More)
BACKGROUND In insulin-dependent diabetes mellitus (IDDM) patients with normal urinary albumin excretion (UAE) controversy exists about the presence of blood pressure (BP) elevation and an attenuation of BP decline during sleep. SUBJECTS AND METHODS These issues were studied in 60 IDDM patients and 55 healthy control subjects with 24 h ambulatory blood(More)
Sixty-three outpatients with endoscopically proven duodenal ulcer and 58 with gastric ulcer were treated under single-blind conditions with either sucralfate, 4 g daily, or with cimetidine, 1 g daily. Endoscopy was performed after 4 weeks and again after 6 weeks if the ulcer had not healed. Among the duodenal ulcer patients, 22 of 31 (71.0%) who received(More)
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