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Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin-dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins(More)
A 33-year-old woman presented with pruritus of the right ear and on examination was found to have 1 x 1 cm polypoid lesion in the external auditory canal. This was removed and histological examination revealed a well-circumscribed spindle cell lesion arranged in fascicles and whorls. Immunohistochemistry showed the tumor to be EMA-positive but S-100-,(More)
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