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Noninvasive monitoring of drug biodistribution and metabolism: studies with intraarterial Pt-195m-cisplatin in humans.
We have performed a comparative evaluation of systemic (i.v.) and intraarterial (i.a.) cisplatin by using a trace dose of the radiolabeled form of this drug [( 195mPt]cisplatin) to monitor the drug'sExpand
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Noninvasive estimation of bound and mobile platinum compounds in the kidney using a radiopharmacokinetic model.
Nephrotoxicity remains a major limitation in the use of cisplatin [cis-diamminedichloroplatinum(II)]. Although several strategies are in use to limit this serious side effect, none is fullyExpand
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A New Approach to Organ Pharmacokinetics Using Noninvasive Radionuclide Measurement Methods
Proper chemotherapy requires that the right dose of the right drug be administered to a given patient at the correct rate. This can be achieved if there is proper monitoring of the drug'sExpand