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Abstract Objective. To evaluate dexmedetomidine for sedation of patients in the medical ICU. Design and setting. Prospective observational study in an intensive care unit of a university hospital. Patients. Twelve ventilated patients with median APACHE II score 23 (range 10–26). Interventions. Patients received a loading dexmedetomidine infusion of 1 µg(More)
The intra-articular injection of local anaesthetic is frequently used for pain relief after arthroscopy. There is, however, no published evidence of the analgesic effect of bupivacaine in the ankle. In a randomised, double-blind study, 35 patients undergoing arthroscopy of the ankle were allocated to receive intra-articular saline or bupivacaine. Pain was(More)
In response to a need for an easily used general-purpose rating scale designed specifically for the evaluation of pharmacotherapy in senile dementia and related conditions, the Sandoz Clinical Assessment-Geriatric (SCAG) scale was developed. This scale has been widely used in geriatric psychopharmacologic research and has been found to be sensitive, valid,(More)
BACKGROUND The induction of general anaesthesia is associated with the greatest cardiovascular changes in elderly patients. Induction can be performed either intravenously or with gaseous induction. Sevoflurane has advantages over propofol for induction of anaesthesia in the elderly, since the lower reduction in mean arterial pressure with sevoflurane is(More)
Introduction A growing body of evidence suggests even small rises in serum creatinine (SCr) are of considerable clinical relevance. Given that participants in endurance events are exposed to potential (repeated) renal insults, a systematic review was undertaken to collate current evidence for acute kidney injury (AKI), complicating such events. Methods A(More)