R D Siubaev

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Nifedipine and verapamil (10 mg/kg orally) were found to induce a significant increase of renin activity, a decrease of aldosterone and ionized calcium levels in blood plasma in spontaneously hypertensive rats. A preliminary administration of a hypertonic solution of sodium chloride decreased renin activity, ionized calcium and aldosterone levels that(More)
Parmidin in 10(-9)-10(-5) g/ml concentrations displays specific and competitive antagonism to spasmogenic effects of bradykinin and methionyl-lysil-bradykinin on isolated segments of the guinea pig ileum, rat uteral cornua, cat jejunum and spiral strips of the rabbit aorta. Its antagonism to the spasmogenic effect of lysil-bradykinin is of both competitive(More)
It has been demonstrated in rat experiments that the beta-adrenoblockers propranolol and pindolol differ in the influence on the therapeutic and toxic effects of voltaren and acetylsalicylic acid. Propranolol has an analgetic action of its own, reducing the analgetic and antiinflammatory effects of voltaren and acetylsalicylic acid. It potentiates the(More)
The effects of new antitumor drugs spirobromin and prospidin on acute (carraghenin-induced rat paw edema) and chronic ("pellet granuloma") inflammation in rats were studied. The drugs were found to exert the anti-inflammatory effect on the model of chronic proliferative inflammation but to produce no significant changes in the degree of the acute(More)
It has been demonstrated on isolated guinea-pig ileum and rats that nonsteroid antiinflammatory drugs (acetylsalicylic acid, ibuprofen, diclofenac sodium, butadione, and indomethacin) antagonized spasmogenic and inflammatory effects of sodium arachidonate, but not of other mediators of inflammation such as histamine, serotonin, bradykinin and PGE2.(More)
Experimental carragenin paw edema in rats, crams in rats induced by acetic acid, and yeast fever in rats were used to study antiexudative, analgetic and antipyretic action of 9 present-day non-steroidal anti-inflammatory drugs (acetylsalicylic acid, amidopyrin, analgin, phenylbutazone, mephenamic acid, voltaren, ibuprofen, indomethacin, naproxen). The(More)
On the isolated segments of the ileum of the guinea-pig, anesthetized and nonanesthetized rats and mice it was established that calcium ion antagonists from different chemical series exert the nonspecific antibradykinin action, reducing the main biological effects of bradykinin--myotropic, depressor, nociceptive and microcirculatory. To a greater extent the(More)
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