R D Holsten

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Aged rodents compared to young rodents are impaired in making repeated reversals and more variable in performance on many tasks. In the present study, a comparison of ten aged (21 months) and 10 young (3 months) Sprague-Dawley rats on a repeated spatial discrimination reversal water escape task revealed that the deficient and variable performance of the(More)
Glucose has previously been shown to improve performance on memory tasks and to ameliorate performance deficits induced by scopolamine or morphine. To test the generality of these observations, Sprague-Dawley rats were trained to alternate choices to reach an escape platform in a two-choice circular water maze. The rats attained a high level of alternation,(More)
In an attempt to clarify the nature of the memory cues used in a spatial, working memory task, rats were tested in a two-choice water maze. Each trial consisted of an information run, which forced the rat to the correct choice compartment, a retention period, and a test run. A response-associated cue condition, in which the relevant cue was the direction of(More)
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