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- Bruno Delord, Arno J. Klaassen, Yves Burnod, R. Costalat, Emmanuel Guigon
- Neuroreport
- 1997

Intracellular recordings have shown that neocortical pyramidal neurones have an intrinsic capacity for regenerative firing. The cellular mechanism of this firing was investigated by computer simulations of a model neurone endowed with standard action potential and persistent sodium (gNaP) conductances. The firing mode of the neurone was determined as a… (More)

- Agnès Aubert, R. Costalat, Romain Valabregue
- Acta biotheoretica
- 2001

In order to make an attempt at grouping the various aspects of brain functional imaging (fMRI, MRS, EEG-MEG, ...) within a coherent frame, we implemented a model consisting of a system of differential equations, that includes: (1) sodium membrane transport, (2) Na/K ATPase, (3) neuronal energy metabolism (i.e. glycolysis, buffering effect of… (More)

- Bruno Delord, Pierre Baraduc, R. Costalat, Yves Burnod, Emmanuel Guigon
- Journal of Computational Neuroscience
- 2000

We analyzed the cellular short-term memory effects induced by a slowly inactivating potassium (Ks) conductance using a biophysical model of a neuron. We first described latency-to-first-spike and temporal changes in firing frequency as a function of parameters of the model, injected current and prior history of the neuron (deinactivation level) under… (More)

- Stéphane Genet, R. Costalat, Joachim Burger
- Biophysical journal
- 2001

An electro-osmotic model is developed to examine the influence of plasma membrane superficial charges on the regulation of cell ionic composition. Assuming membrane osmotic equilibrium, the ion distribution predicted by Gouy-Chapman-Grahame (GCG) theory is introduced into ion transport equations, which include a kinetic model of the Na/K-ATPase based on the… (More)

- R. Costalat, Joachim Burger
- Bulletin of mathematical biology
- 1996

Yates-Pardee-type metabolic pathways in a heterogeneous cell milieu are modeled as a system of coupled non-linear partial differential equations. A numerical solution to this system is described and some properties of such a physiological system are studied. Confinement with and without a membrane is considered and it is shown how confinement results in an… (More)

- Stéphane Genet, R. Costalat, Joachim Burger
- Acta biotheoretica
- 2000

The role of fixed charges present at the surface of biological membranes is usually described by the Gouy-Chapman-Grahame theory of the electric double-layer where the Grahame equation is applied independently on each side of the membrane and where the capacitive charges (linked to the transmembrane ionic currents) are disregarded. In this article, we… (More)

- Gilbert Chauvet, R. Costalat
- Comptes rendus de l'Académie des sciences. Se…
- 1995

In this paper, we have considered how the spatial localization of enzymatic reactions, ranging from the elementary type (one step) to that of a metabolic pathway in 2 different phases, may affect the stability of metabolite concentrations. The spatial localization of molecules in the reactions involves: (1) the confinement of some enzymes to cellular… (More)

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