R. Christopher Doty

Learn More
A number of mouse models for spinal muscular atrophy (SMA) have been genetically engineered to recapitulate the severity of human SMA by using a targeted null mutation at the mouse Smn1 locus coupled with the transgenic addition of varying copy numbers of human SMN2 genes. Although this approach has been useful in modeling severe SMA and very mild SMA, a(More)
While rapamycin treatment has been reported to have a putatively negative effect on glucose homeostasis in mammals, it has not been tested in polygenic models of type 2 diabetes. One such mouse model, NONcNZO10/LtJ, was treated chronically with rapamycin (14 ppm encapsulated in diet) and monitored for the development of diabetes. As expected, rapamycin(More)
Provenance information is inherently affected by the method of its capture. Different capture mechanisms create very different provenance graphs. In this work, we describe an academic use case that has corollaries in offices everywhere. We also describe two distinct possibilities for provenance capture methods within this domain. We generate three datasets(More)
A spontaneous mutation termed bilateral wasting kidneys (bwk) was identified in a colony of NONcNZO recombinant inbred mice. These mice exhibit a rapid increase of urinary albumin at an early age associated with glomerulosclerosis, interstitial nephritis, and tubular atrophy. The mutation was mapped to a location on chromosome 1 containing the Col4a3 and(More)
Provenance information is inherently affected by the method of its capture. Different capture mechanisms create very different provenance graphs. In this work, we describe an academic use case that has corollaries in offices everywhere. We also describe two distinct possibilities for provenance capture methods within this domain. We generate three data sets(More)
  • 1