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Electric fields generated by single square and sinusoidal voltage pulses with amplitudes below 2 V were used to assist the covalent immobilization of single-stranded, thiolated DNA probes, onto a chemically functionalized SiO2 surface and to assist the specific hybridization of single-stranded DNA targets with immobilized complementary probes. The(More)
The application of on-chip single voltage pulses is used to achieve both temporal and spatial control of the biological reactions in DNA chips. Single square and sinusoidal voltage pulses with amplitudes between 0.1 and 5 V and durations between 20 ns and 10 ms are used to achieve specific DNA oligonucleotide probe covalent immobilization to a(More)
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