R. C. Sharma

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The emergence of multidrug resistance strains of Mycobacterium tuberculosis and the continuing pandemic of tuberculosis (TB) leads to the urgent development of the new potent antitubercular agents. Hence, an effort to develop new and more effective agents to treat TB emphasis was focused on quantification of structure–activity relationship of(More)
Three UV spectrophotometric methods have been developed, simultaneous equation method, multicomponent analysis (II) and derivative spectroscopy method (III). The absorption maxima of the drugs were found to be 247, 259 and 272 nm, respectively for efavirenz, tenofovir disoproxil fumarate and lamivudine in methanol:water (50:50) solvent system. Efavirenz,(More)
A new series of cyclooxygenase-2 inhibitors with 2-amino-5-sulfanyl-1,3,4-thiadiazole as the central scaffold unit has been synthesized. The newly synthesized compounds were characterized by analytical and spectral methods. Compounds were screened for cyclooxygenase inhibitory activity by the colorimetric COX (ovine) inhibitor screening assay,(More)
A high performance reverse phase liquid chromatographic procedure is developed for simultaneous estimation of metformin hydrochloride and pioglitazone hydrochloride in combined tablet dosage form. The mobile phase used was a combination of acetonitrile:water:acetic acid (60:40:0.3) and the pH was adjusted to 5.5 by adding triethylamine. The detection of the(More)
A series of 5-substituted benzimidazoles were designed, synthesized, and evaluated for in vivo antihypertensive activity by acute renal hypertension on guinea pig. All the compounds of the series elicit remarkable activity in comparison to standard drug (losartan). The activity is found to be relatively better in substituted alkylamino group at 5-position(More)
In the present study, a series of 2-amino-5-sulphanyl-1,3,4-thiadiazole derivatives were synthesized in good yields and the structure of these compounds were established by means of FT-IR, 1H/13C NMR, mass, and elemental analysis. The synthesized compounds were screened pharmacologically to evaluate their central nervous system activity. The purpose of this(More)
Oral administration is the most convenient route among various routes of drug delivery as it offers high patient compliance. However, the poor aqueous solubility and poor enzymatic/metabolic stability of drugs are major limitations in successful oral drug delivery. There are several approaches to improve problems related to hydrophobic drugs. Among various(More)