R. C. Garner

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The levels of aflatoxin B(1)-DNA and aflatoxin B(1)-albumin adducts were investigated by accelerator mass spectrometry (AMS) in humans and rats following exposure to a known, dietary relevant amount of carbon-14 labeled aflatoxin B(1) ([(14)C]AFB(1)). The aims of the study were to: (a) investigate the dose-dependent formation of DNA and protein adducts at(More)
Lung cancer is the most common cancer in men in the United Kingdom and the second most common in women, accounting for between 25 and 40% of all cancer deaths. Cigarette smoking is widely accepted as the major cause of lung cancer and linear relationships have been established between the number of cigarettes smoked and lung cancer risk. Although(More)
Although the aflatoxins were discovered more than 30 years ago, there is still considerable controversy surrounding their human health effects. Most countries have introduced legislation to control the level of aflatoxins in food, but it is not known if these permitted levels still pose a significant cancer risk. Furthermore, it is unlikely that all the(More)
Ixabepilone (BMS-247550) is a semi-synthetic, microtubule stabilizing epothilone B analogue which is more potent than taxanes and has displayed activity in taxane-resistant patients. The human plasma pharmacokinetics of ixabepilone have been described. However, the excretory pathways and contribution of metabolism to ixabepilone elimination have not been(More)
  • R C Garner, September, Richard Charles Garner, B A Carleton College, Richard S Post, Thesis Supervisor +2 others
  • 2014
The ECRH, mirror-confined plasma of the Constance B experiment is whistler unstable. Two types of rf emission. referred to as whistler B (bursting) and whistler C (continuous), are observed. The whistler B emission bursts at a fairly regular rate and correlates with electron and ion endloss bursts, and diamagnetism and potential fluctuations. The burst rate(More)
  • T M Antonsen, G Prof, A Bekefi, B Bers, T H Coppi, L M Dupree +147 others
  • 2009
We report on theoretical and computational work related to studies of waves in plasmas. This group's work is aimed at understanding large-amplitude, coherent waves in a plasma in general, and their use in plasma heating in particular. Progress on four research topics is described. (a) Nonlinear Waves in the Presence of Collisions The one-dimensional(More)
The binding of metabolites of BP to added native or denatured DNA catalysed by rat liver microsomes, and to endogenous DNA catalysed by rat liver nuclei, was studied by hydrolysis of the isolated DNA and column chromatography on LH20 Sephadex. The same 2 major deoxyribonucleoside-hydrocarbon products were obtained from micro-somes and from nuclei. That(More)
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