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Unresponsiveness to dinitrochlorobenzene (DNCB) in chickens sensitised with a supraoptimal dose of DNCB (2.5 mg/bird) is an active process mediated by spleen lymphoid cells. Preparations of spleen lymphocytes/monocytes, or non-adherent spleen lymphocytes alone, from supraoptimally sensitised chickens, when transferred into optimally sensitised outbred(More)
Delayed hypersensitivity to DNCB in chickens is a dose-dependent reaction. It could be induced by a single painting of the skin with 1 mg of DNCB/bird without adjuvant and could be elicited at a challenge site with 50 mug DNCB. The sensitisation lasted for several weeks, and was mediated by sensitised lymphoid cells which required the presence of autologous(More)