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In synaptosomes from rat substantia nigra pars reticulata, [3H] gamma-aminobutyric acid (GABA) uptake was inhibited by GABA, (+/-)-nipecotic acid, beta-alanine and SKF 89976-A. Inhibition was concentration-dependent and monophasic, with IC50 values that agree with those reported for the cloned rat GABA transporter GAT-1. [3H]GABA uptake was modestly, but(More)
In membranes of rat thalamus the density of histamine H1 receptors, as estimated from saturation curves with [3H]mepyramine, was 66 +/- 5 fmol.mg protein-1 (Kd 1.3 +/- 0.1 nM). Specific [3H]mepyramine binding was inhibited by mepyramine (best fit to one-site model, Kd 2.2 +/- 0.2 nM) and by histamine (best fit to a two-site model, Ki high 0.35 +/- 0.04(More)
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