R.B. Schulz

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We have extended our previously introduced hybrid phantom model to allow for phantom representation by higher-order surfaces (point meshes, polygonal meshes) in addition to any combination of intrinsic shapes (cubes, quadrics, super-quadrics) and voxel data originating from tomography (segmented CT/MRI volumes). Higher-order surfaces can be represented by(More)
Both fundamental and state-of-the-art limits are treated, with emphasis on the former. Fundamental limits result from both natural and man-made electromagnetic noise which then affect two basic ratios, signal-to-noise (S/N) and extraneous-input-to-noise (I/N). Tolerable S/N values are discussed for both digital and analog communications systems. These lead(More)
Herein, we present a novel concept for fully integrated dual-modality in vivo tomographic imaging yielding simultaneous detection of positron and optically labeled probes in small animals. The imager consists of an allocation of optical detector modules and, in radial extension, the allocation of positron emission detector modules. Laser scanning and(More)
We present a Monte Carlo feasibility study of a device designed to simultaneously image positron labeled substrates and optical molecular probes in small animals such as mice and rats. The acquisition arrangement constitutes an entirely novel imaging system considering the dual-modality feature as well as the integrated non-contact optical detection(More)
We have developed a novel Monte Carlo simulation code for time-resolved simultaneous migration of optical and isotopic photons through 4D hybrid phantom media. Phantoms consist of parameterized regions with spatial varying material, activity, and wavelength-dependent optical properties (scatter, attenuation, anisotropy) which can be represented by implicit(More)
We have developed a dual-modality single photon (SPECT)/optical (OT) small animal tomographic device to image simultaneously and from identical projection angles in vivo distributions of bioluminescent/(near-infrared) fluorescent and radiolabeled markers. For the SPECT sub-system a compact gamma detector has been developed. A custom-made pinhole (PH)(More)
We present herein the development of a fully 360/spl deg/ rotatable fluorescence tomography system for small animals without the use of source and detector fibers, or optically matching fluids. The setup consists of a cooled CCD camera coupled to a wide-angle objective and an axially moveable, collimated laser source integrated within a rotating light-tight(More)
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