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We describe a Bayesian inference scheme for quantifying the active physiology of neuronal ensembles using local field recordings of synaptic potentials. This entails the inversion of a generative neural mass model of steady-state spectral activity. The inversion uses Expectation Maximization (EM) to furnish the posterior probability of key synaptic(More)
OBJECTIVE To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). METHODS Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive(More)
Parametric modelling strategies and spectral analysis are explored in conjunction with Linear Discriminant Analysis to facilitate an EEG based direct-brain interface for use by disabled people. A self-paced typing exercise is analysed by employing for feature extraction, respectively, an autoregressive model, an autoregressive with exogenous input model,(More)
Z3is study investigated the automatic prediction of epochs of sleep apnea from the electrocardiogram. A large independently validated database of 70 single lead ECGs, each of approximately 8 hours in duration, was used throughout the study. Thirty five of these records were used for training and 35 retained for independent testing. Ajier considering a wide(More)
Adult-onset primary torsion dystonia (AOPTD) is an autosomal dominant disorder with markedly reduced penetrance. Sensory abnormalities are present in AOPTD and also in unaffected relatives, possibly indicating non-manifesting gene carriage (acting as an endophenotype). The temporal discrimination threshold (TDT) is the shortest time interval at which two(More)
Functional magnetic resonance imaging (FMRI) is an imaging technique for determining which regions of the brain are activated in response to a stimulus or event. Early FMRI experiment paradigms were based upon those used in positron emission tomography (PET), i.e. employing a block design consisting of extended periods of 'on' against 'off' activations.(More)
Electroencephalogram (EEG) data are typically contaminated with artifacts (e.g., by eye movements). The effect of artifacts can be attenuated by deleting data with amplitudes over a certain value, for example. Independent component analysis (ICA) separates EEG data into neural activity and artifact; once identified, artifactual components can be deleted(More)
BACKGROUND The no-go P3a is a variant of the P300 event-related potential (ERP) that indexes speed of information processing and attention allocation. The aim of this study was to compare ERP findings with results from the paced auditory serial addition test (PASAT) and to quantify latency, amplitude and topographical differences in P3a ERP components(More)
Familial adult-onset primary torsion dystonia is an autosomal dominant disorder with markedly reduced penetrance. Most adult-onset primary torsion dystonia patients are sporadic cases. Disordered sensory processing is found in adult-onset primary torsion dystonia patients; if also present in their unaffected relatives this abnormality may indicate(More)