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We describe a Bayesian inference scheme for quantifying the active physiology of neuronal ensembles using local field recordings of synaptic potentials. This entails the inversion of a generative neural mass model of steady-state spectral activity. The inversion uses Expectation Maximization (EM) to furnish the posterior probability of key synaptic(More)
OBJECTIVE To quantify latency, amplitude and topographical differences in event-related potential (ERP) components between multiple sclerosis (MS) patients and controls and to compare ERP findings with results from the paced auditory serial addition test (PASAT). METHODS Fifty-four subjects (17 relapsing remitting (RRMS) patients, 16 secondary progressive(More)
Parametric modelling strategies and spectral analysis are explored in conjunction with Linear Discriminant Analysis to facilitate an EEG based direct-brain interface for use by disabled people. A self-paced typing exercise is analysed by employing for feature extraction, respectively, an autoregressive model, an autoregressive with exogenous input model,(More)
Z3is study investigated the automatic prediction of epochs of sleep apnea from the electrocardiogram. A large independently validated database of 70 single lead ECGs, each of approximately 8 hours in duration, was used throughout the study. Thirty five of these records were used for training and 35 retained for independent testing. Ajier considering a wide(More)
This study investigates the automatic classification of the Frank lead electrocardiogram (ECG) into different pathophysiological disease categories. Coefficients from the discrete wavelet transform are used to represent the ECG diagnostic information and a comparison of the performance of classifiers processing feature sets generated using different mother(More)
Adult-onset primary torsion dystonia (AOPTD) is an autosomal dominant disorder with markedly reduced penetrance. Sensory abnormalities are present in AOPTD and also in unaffected relatives, possibly indicating non-manifesting gene carriage (acting as an endophenotype). The temporal discrimination threshold (TDT) is the shortest time interval at which two(More)
Functional magnetic resonance imaging (FMRI) is an imaging technique for determining which regions of the brain are activated in response to a stimulus or event. Early FMRI experiment paradigms were based upon those used in positron emission tomography (PET), i.e. employing a block design consisting of extended periods of 'on' against 'off' activations.(More)
Electroencephalogram (EEG) data are typically contaminated with artifacts (e.g., by eye movements). The effect of artifacts can be attenuated by deleting data with amplitudes over a certain value, for example. Independent component analysis (ICA) separates EEG data into neural activity and artifact; once identified, artifactual components can be deleted(More)
This paper presents an implementation of an effective EEG-based Brain Computer Interface design as the control mechanism for an immersive 3-D game. The BCI is based on the application of the steady-state visual evoked potential (SSVEP) generated in response to phase-reversing checkerboard patterns. Real-time game control and signal processing is facilitated(More)