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We describe an information seeking assistant for the world wide web. This agent, called WebWatcher, interactively helps users locate desired information by employing learned knowledge about which hyperlinks are likely to lead to the target information. Our primary focus to date has been on two issues: (1) organizing WebWatcher to provide interactive advice(More)
These experiments were designed to study skeletal muscle pathology resulting from eccentric-biased exercise in rats. The effects on the muscles of running on a treadmill on a 0 degrees incline (similar amounts of concentric and eccentric contractions), down a 16 degrees incline (primarily eccentric contractions), and up a 16 degrees incline (primarily(More)
The purpose of this study was to estimate the absolute and relative masses of the three types of skeletal muscle fibers in the total hindlimb of the male Sprague-Dawley rat (Rattus norvegicus). For six rats, total body mass was recorded and the following weights taken from dissection of one hindlimb: 32 individual major muscles or muscle parts, remaining(More)
Delayed-onset muscular soreness (DOMS), the sensation of pain and stiffness in the muscles that occurs from 1 to 5 d following unaccustomed exercise, can adversely affect muscular performance, both from voluntary reduction of effort and from inherent loss of capacity of the muscles to produce force. This reduction in performance is temporary; permanent(More)
The objective of this review is to evaluate the measurement tools currently used in the study of eccentric contraction-induced muscle injury, with emphasis on their usefulness for quantifying the magnitude and duration of the injury and as indicators of muscle functional deficits. In studies in humans, it was concluded that measurements of maximal voluntary(More)
Immediately following unaccustomed exercise, particularly that with eccentric contractions, there is evidence of injury to skeletal muscle fibers: a) disruption of the normal myofilament structures in some sarcomeres, observable with both light and electron microscope and b) loss of intramuscular proteins (e.g., creatine kinase enzymes) into the plasma,(More)
Exercise for which a skeletal muscle is not adequately conditioned results in focal sites of injury distributed within and among the fibres. Exercise with eccentric contractions is particularly damaging. The injury process can be hypothesised to occur in several stages. First, an initial phase serves to inaugurate the sequence. Hypotheses for the initial(More)
GOLLNICK, P. D., R. B. ARMSTRONG, C. W. SAUBERT IV, K. PIEHL, AND B. SALTIN. Enzyme activity and Jiber composition in skeletal muscle of untrained and trained men. J. Appl. Physiol. 33(3): 3 12-3 19, 1972.-Succinate dehydrogenase (SDH) and phosphofructokinase (PFK) activities and the histochemical identification of fiber types and localization of oxidative(More)
We describe a simple and reproducible procedure for measuring maximal O2 consumption (Vo2max) that can be used for mammals spanning a wide range of body mass (Mb). Vo2 of trained animals was measured as a function of speed while they ran on a treadmill. Lactate concentration of the blood was determined at the beginning and end of the run. We considered that(More)