R A Merlock

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The naturally occurring enediyne antibiotics, which include calicheamicin, esperamicin, neocarzinostatin, kedarcidin and dynemicin, are a unique class of reactive compounds which can undergo aromatization to produce cytotoxic biradicals and can result in phosphodiester bond breakage of DNA. Synthetic enediynes designed with low molecular complexity are also(More)
We have investigated the biodistribution, toxicity, and antitumor activity of a new type of synthetic compound containing an enediyne functional group capable of benzenoid diradical generation. The design of this cytotoxic molecule was based on the structures of naturally occurring enediyne antibiotics. Compared to the natural compounds, the synthetic(More)
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