R A Burchuladze

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The role of protein kinase C (PKC) in the formation of memory for a one-trial passive avoidance task in 1-day-old chicks has been studied, following earlier observations that training on this task results in transient and lateralised changes in the phosphorylation state of presynaptic B-50 protein, a PKC substrate. In accord with hypotheses that the(More)
The effects of new cyclic analogs of ACTH fragments, EHFRWGKPVG-NH2 and KHFRWG-NH2, which have specific and nonspecific active centers in their structure, in the self-stimulation, avoidance, and grooming behavior of rabbits were investigated in this study. The intraventricular administration of EHFRWGKPVG-NH2 in doses of 0.1-2.5 micrograms increased the(More)
Unilateral lesions of septal region, which partially included commissure anterior, commissural nuclei, fornix and apical parts of medial and lateral preoptic area, inhibited hypothalamic self-stimulation in rabbits. Intraventricular injection of ACTH (4-10) and ACTH (1-24) evoked the restoration of self-stimulation behaviour.
Unilateral lesions of medial septal nucleus and lateral septal nuclei (dorsalis, intermedius, ventralis) decreased ipsilateral hypothalamic self-stimulation; the lesions of n. dorsalis, n. medialis and lateral septal nuclei (intermedius and ventralis) has the opposite effect on contralateral self-stimulation. The inhibition of ipsilateral self-stimulation(More)
In present study new cyclic fragments of ACTH EHFRWGKPVG--NH2 and KHFRWG--NH2 were investigated in organization of self-stimulation and grooming behaviour in rabbits. Intracerebroventricular injections of EHFRWGPVG--NH2 in doses of 0.1-2.5 g evoked significant increases of self-stimulation and in doses of 4-5 g suppressed self-stimulation in rabbits. The(More)
The experiments on rabbits have demonstrated that blockade of protein synthesis by the administration of cycloheximide and actinomycin D abolishes self-stimulation in the central nervous system. The treatment with ACTH fragment (ACTH4-10) restored the self-stimulation. Unlike ACTH, injections of pentagastrin, Met-enkephalin, Leu-enkephalin and(More)
The effect of i. v. administration of angiotensin II, substance P, DSIP, B-endorphin and bradykinin on the behaviour and the somato-vegetative responses to electrical stimulation of negative and positive emotiogenic regions of the hypothalamus, were studied. Angiotensin II, substance P and DSIP suppressed the avoidance and self-stimulation responses and(More)
The influence of increasing electrodermal stimulation (EDS) on the dynamics of the somatovegetative reactions evoked by electrical stimulation of negative emotiogenic regions of the hypothalamus was studied. EDS produced a blocking effect on the somatovegetative reactions evoked by stimulation of the ventromedial hypothalamus (VMH). Pretreatment with(More)
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