R. A. Burchuladze

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The role of protein kinase C (PKC) in the formation of memory for a one-trial passive avoidance task in 1-day-old chicks has been studied, following earlier observations that training on this task results in transient and lateralised changes in the phosphorylation state of presynaptic B-50 protein, a PKC substrate. In accord with hypotheses that the(More)
Unilateral lesions of septal region, which partially included commissure anterior, commissural nuclei, fornix and apical parts of medial and lateral preoptic area, inhibited hypothalamic self-stimulation in rabbits. Intraventricular injection of ACTH (4-10) and ACTH (1-24) evoked the restoration of self-stimulation behaviour.
Self stimulation is formed on an emotional basis of subjective sensations. An important role in the formation of self-stimulation behavior, based on ascending activating influences of the emotiogenic structures of the brain, has been shown to be played by endogenous oligopeptides [i, 3, 4]. It can accordingly be postulated that self-stimulation behavior,(More)
a latent period of 0.7-4.0 msec were obtained in eight of the nine expira tory neurons of the ventral r e sp i r a to ry nucleus. The latent period in complete and late neurons was under 1.2 msec . During threshold stimulation evoked discharges of expiratory neurons were observed only in the phase of expiration, but with an increase in strength of the(More)
The effect of i. v. administration of angiotensin II, substance P, DSIP, B-endorphin and bradykinin on the behaviour and the somato-vegetative responses to electrical stimulation of negative and positive emotiogenic regions of the hypothalamus, were studied. Angiotensin II, substance P and DSIP suppressed the avoidance and self-stimulation responses and(More)
We studied the influence of new cyclic analogues of ACTH fragments EHFRWGKPVG-NH2 and KHFRVG-NH2 on self-stimulation (SS) and active avoidance (AA) behaviour. Intraventricular injection of EHFRWGKPVG-NH2 in low doses (0.5-2.5 mcg) was shown to increase, that in higher doses (4-5 mcg) to decrease SS frequency. Injection of KHFRWG-NH2 in doses of 0.1-5 mcg(More)
In present study new cyclic fragments of ACTH EHFRWGKPVG--NH2 and KHFRWG--NH2 were investigated in organization of self-stimulation and grooming behaviour in rabbits. Intracerebroventricular injections of EHFRWGPVG--NH2 in doses of 0.1-2.5 g evoked significant increases of self-stimulation and in doses of 4-5 g suppressed self-stimulation in rabbits. The(More)
8. 9. 10. 11. 12. 13. 14. 15. D. L. Kaminski and J. Desphande, Hepatology, 6, No. 2, 275 (1986). D. L. Kaminski, J. Desphande, L. Thomas, and W. Blank, Prostagland. Leucotr. Med., 16, No. 3, 109 (1984). I. Morita and S. Murota, Biochim. Biophys. Acta, 619, 428 (1980). IC Nakata and IC Kurahashi, Jpn. J. Pharmacol., 31, 77 (1981). T. Okumura and K. Saito, J.(More)
Unilateral lesions of medial septal nucleus and lateral septal nuclei (dorsalis, intermedius, ventralis) decreased ipsilateral hypothalamic self-stimulation; the lesions of n. dorsalis, n. medialis and lateral septal nuclei (intermedius and ventralis) has the opposite effect on contralateral self-stimulation. The inhibition of ipsilateral self-stimulation(More)
The influence of increasing electrodermal stimulation (EDS) on the dynamics of the somatovegetative reactions evoked by electrical stimulation of negative emotiogenic regions of the hypothalamus was studied. EDS produced a blocking effect on the somatovegetative reactions evoked by stimulation of the ventromedial hypothalamus (VMH). Pretreatment with(More)