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RATIONALE AND OBJECTIVES Comparison of two different diffusion weighted (DW) sequences in breast MRI regarding the differentiation between benign and malignant lesions. MATERIALS AND METHODS Breast MRI including two different DW sequences was performed in 165 consecutive women. Inclusion criteria for DW imaging and ADC evaluation were histologically(More)
BACKGROUND Vacuum-assisted breast biopsy (VAB) can replace surgical biopsy for the diagnosis of breast carcinoma. The authors evaluated the accuracy and clinical utility of VAB in a multicenter setting using a strict quality assurance protocol. METHODS In the current study, VABs were performed successfully for 2874 patients at 5 sites. Benign lesions were(More)
Between 1992 and 1993, 307 ultrasonic guided highspeed core cut biopsies were performed. In 119 of the 307 women, we dispensed with further surgical and histological procedures when the tentative diagnosis from complementary mammary diagnostic procedures revealed no pathological findings and concurred with the histological results of the core cut biopsy. In(More)
Sowohl im Rahmen der komplementären Mammadiagnostik (Klinik, Mammographie, Sonographie) einschließlich der dynamischen MRT als auch von Mammakarzinom-Screening-Projekten haben interventionelle Methoden wie die mammographisch/stereotaktisch gezielte Vakuum-/Exzisionsbiopsie ihren festen Stellenwert zur Vermeidung unnötiger offener Operationen und gehören(More)
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as(More)
INTRODUCTION MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators of gene expression thereby affecting crucial processes in cancer development. MiRNAs offer great potential as biomarkers for cancer detection due to their remarkable stability in blood and their characteristic expression in many different(More)
Purpose.Mammography (MG), breast (BU) and axillary ultrasound (AU), and clinical examination (CE) are commonly used for clinical staging. These different methods were compared in order to assess the accuracy of clinical tumor staging (cT). Method.About 503 breast cancer (BC) patients were prospectively measured by MG, ultrasound and clinical examination.(More)
Breast volume is a relevant measure for the prevention and prediction of diseases and for aesthetic surgery. This study evaluated a new technique to determine breast volume and compared measures using a three-dimensional (3D) body surface scanner and magnetic resonance imaging (MRI) scans, with the latter used as the standard method. Both MRI scans and body(More)
Mammography is the most effective method for breast cancer screening available today. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. To reduce the high number of unnecessary breast biopsies, several computer-aided diagnosis (CAD)(More)
The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of predicting a pCR, such as the proliferation marker Ki67, may therefore help improve our understanding of the drug response and its effect on the prognosis. This study investigated the(More)