Rüdiger G. W. Osmers

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METHODS: This randomized, multicenter, double-blind clinical trial compared the efficacy and tolerability of the isopropanolic black cohosh extract in the treatment of climacteric complaints compared with placebo. A total of 304 patients were randomly allocated to receive tablets corresponding to 40mg drug ormatching placebo daily for 12 weeks. The primary(More)
Einleitung: Die Prognose angeborener Herzfehler hat sich in den letzten Jahrzehnten drastisch verbessert. Gleichzeitig hat auch die Zahl von Frauen mit einem angeborenen Herzfehler, die schwanger werden, stark zugenommen. Bislang existieren dennoch kaum aktuelle prospektive Daten über den Schwangerschaftsverlauf bei Frauen mit angeborenen Herzfehlern. Ziel(More)
Real-time PCR methods for the detection of RHD and the C, c, and E allele of RHCE were applied for the prediction of fetal Rh phenotype using maternal plasma. In one of 36 samples investigated the DNA extraction failed. When we tested the remaining 35 samples for Rh antigens which were absent on the mother's red cells, the fetal D-status was correctly(More)
OBJECTIVE Black cohosh, a popular herbal treatment for menopausal symptoms, has been implicated in a number of hepatotoxicity case reports. The purpose of this investigation was to analyze data gained from clinical trials on the effect of black cohosh on liver function. METHODS A meta-analysis of randomized, double-blind, and controlled clinical trials(More)
Menopausal symptoms management with high-quality plant extracts from Actaea (Cimicifuga. racemosa rootstock is well-established. Efficacy and safety are supported by research and clinical trials since several decades and backed up by official monographs. However, the recent published Cochrane review on black cohosh neglects major evidence for beneficial(More)
Oligo- and polyhydramnios could be observed in 1%–7% of all pregnancies and are associated with an increased risk of fetal anomalies. We evaluated the fetal outcomes of 840 pregnancies with oligo- and polyhydramnios on the basis of ultrasonographic findings (oligohydramnios: single deepest pocket <2 cm, polyhydramnios: single deepest pocket >8 cm) between(More)
Da Endometriumkarzinome aus hormonabhängigen Zellen hervorgehen, spielen nebenwirkungsarme endokrine Manipulationen in der palliativen Therapie fortgeschrittener Fälle traditionell eine große Rolle. Umfangreiche Untersuchungen wurden über den Wert einer adjuvanten endokrinen Therapie beim Endometriumkarzinom durchgeführt. In der konservativen Therapie von(More)
Die Teilnehmerinnen der Studie beurteilten das Modell uneingeschrfinkt positiv. Die Vertrauensbasis zur eigenen Hebamme war hierfiir ausschlaggebend. Die Hebamme war Ansprechpartner vor der Geburt und ihr wurde in der Ausnahmesituation der Entbindung vertraut. Sie war damit Garant fiir eine Geburt in angstfreier Atmosph/ire. Dartiber hinaus erm6glichte sie(More)