Régis Laurent

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Dendrimers pertain both to the molecular chemistry world for their step by step controlled syntheses, and to the polymer world because of their repetitive structure made of monomers; thus they benefit from analytical techniques from both worlds. This review is a survey of the main analytical techniques used for the characterization of the chemical(More)
Novel multivalent copper(II)-conjugated phosphorus dendrimers and their corresponding mononuclear copper(II) complexes were synthesized, characterized, and screened for antiproliferative activity against human cancer cell lines. Selected copper ligands were grafted on the surface of phosphorus dendrimers of generation G(n) (n = 1 to 3):(More)
Biosensors such as DNA microarrays and microchips are gaining an increasing importance in medicinal, forensic, and environmental analyses. Such devices are based on the detection of supramolecular interactions called hybridizations that occur between complementary oligonucleotides, one linked to a solid surface (the probe), and the other one to be analyzed(More)
The dendritic (or dendrimer) effect is observed when a functional group behaves differently when it is alone or linked to a dendrimer; its properties can even vary depending on the generation of the dendrimers. The dendritic effect can be observed with any type of dendrimer, and for any type of property, even if it has been most generally tracked in(More)
Dendrimers are hyperbranched nanosized and precisely defined molecules, attracting increasing attention each year due to their numerous properties in catalysis, materials science, and biology. This tutorial review concerns the use of dendrimers as catalysts and focuses more precisely on their properties as enantioselective catalysts. Emphasis is put on(More)
Functionalized phenols based on tyramine were synthesized in order to be selectively grafted on to hexachlorocyclotriphosphazene, affording a variety of functionalized dendrons of type AB(5). The B functions comprised fluorescent groups (dansyl) or dyes (dabsyl), whereas the A function was provided by either an aldehyde or an amine. The characterization of(More)
Generations 1 to 3 of dendrimers ended by water-soluble phosphines are synthesized and their ruthenium complexes are used as catalysts in aqueous media; a slightly positive dendritic effect on the regioselectivity is observed for hydration of alkynes and a large positive dendritic effect is observed in the biphasic (water/heptane) catalysed isomerisation of(More)
Imino pyridine-capped phosphorus dendrimers were found to strongly enhance the catalytic activity of copper in arylations and vinylations of O- and N-nucleophiles. These reactions could indeed be performed under very mild conditions, often the mildest to date. Interestingly, such performances could not be obtained when using the monomeric imino pyridine(More)
Dendrimers are multifunctional, hyperbranched and perfectly defined macromolecules, synthesized layer after layer in an iterative manner. Besides the nature of the terminal groups responsible for most of the properties, the nature of the internal structure, and more precisely of the branching points, is also of crucial importance. For more than 15 years, we(More)
Phosphorus dendrimers containing terminal phosphoramidite ligands have been found to be highly effective and recoverable catalysts for the rhodium(I) catalyzed [2+2+2] cycloaddition reactions. A strong positive dendritic effect is observed both in the activity and enantiodiscrimination leading to axially chiral biaryl compounds.