Régis Angonin

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Administration of donor T cells expressing the herpes simplex-thymidine kinase (HS-tk) with a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease (GVHD) was to occur, a selective in vivo depletion of these T cells by the use of ganciclovir (GCV). The study evaluates the feasibility of such an approach. Escalating numbers(More)
We report on the characteristics of 21 patients with hepatosplenic ␥␦ T-cell lymphoma (HS␥␦TCL), an entity recognized since 1994 in the Revised Euro-pean American Lymphoma (REAL) classification. Median age was 34 years. Patients had splenomegaly (n ‫؍‬ 21), hepatomegaly (n ‫؍‬ 15), and thrombocy-topenia (n ‫؍‬ 20). Histopathologic findings were homogeneous(More)
The use of donor T cells expressing a suicide gene for destruction of graft-versus-host effector cells provides a tool for alloreactivity modulation. We describe a case of extensive vitiligo that developed after ganciclovir treatment of cutaneous chronic graft-versus-host disease in a patient who had received donor T lymphocytes expressing herpes simplex(More)
Is the inframammary fold an anatomical entity? In order to answer this question, the authors conducted an anatomical, histological and radiological study. The results of these studies were concordant and were able to anatomically define the inframammary fold. The inframammary fold corresponds to a division of the fascia superficialis. It contains numerous(More)
m. MARCKS is a ubiquitous protein kinase C substrate which interacts with cahncdulh~ and cross-links the actin filaments Its cellular function is probably related to the regulation of these two proteins. MARCKS is also a physiological substrate for prolio&irected kinase.s like cyclin-dependent kinasea (cdks) and MAP kinases. The expression of MARCKS is high(More)
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