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Elevated total plasma homocysteine (tHcy) concentrations are considered a risk factor for neural tube defects (NTD) and cardiovascular disease. Supplementation with folic acid decreases the risk of women having children with NTD. In both sexes, it decreases tHcy levels. We investigated the efficacy of natural dietary folate in improving folate and(More)
OBJECTIVE To establish the prevalence of hyperhomocysteinemia in women with unexplained recurrent early pregnancy loss. DESIGN In a patient-control study, the methionine-homocysteine metabolism was investigated by a standardized oral methionine-loading test. SETTING Gynecologic outpatient department of university hospital. PATIENTS One-hundred and two(More)
BACKGROUND Thiols are scavengers of reactive oxygen species (ROS). We aim to investigate associations between thiols in various fluids in (sub)fertile couples and fertility outcome parameters. METHODS In 156 couples undergoing assisted reproduction techniques (ART), we measured the concentrations of glutathione (GSH), cysteine (Cys), homocysteine (Hcy)(More)
BACKGROUND The incidence of overweight and obesity in men of reproductive ages is rising, which may affect fertility. Therefore, this study aims to assess the associations between BMI, central adiposity and sperm parameters in men of subfertile couples. METHODS Ejaculate volume (ml), sperm concentration (millions per ml), percentage of progressive motile(More)
CONTEXT Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. OBJECTIVE Our objective was to identify changes in lipid metabolism in women with PCOS, and the(More)
Current treatments of subfertile couples are usually empiric, as the true cause of subfertility often remains unknown. Therefore, we outline the role of nutritional and biochemical factors in reproduction and subfertility. A literature search was performed using MEDLINE, Science Direct and bibliographies of published work with both positive and negative(More)
OBJECTIVE To study the effects of folic acid and zinc sulfate treatment on semen variables in fertile and subfertile men. DESIGN Double-blind, placebo-controlled interventional study. SETTING Two outpatient fertility clinics and nine midwifery practices in The Netherlands. PARTICIPANT(S) One hundred eight fertile and 103 subfertile men. (More)
OBJECTIVE To review possible causes for male factor subfertility with emphasis on nutritional factors such as zinc and folate. DESIGN A literature search was performed on MEDLINE and via bibliographies of published works. RESULT(S) Many causes for male factor subfertility are described in the literature. Both environmental and genetic factors could play(More)
BACKGROUND An elevated plasma total homocysteine concentration is a risk factor for cardiovascular disease and neural tube defects. A high daily intake of supplemental folic acid is known to decrease total homocysteine concentrations. OBJECTIVE We studied the effect of low-dose folic acid administration (250 or 500 (microgram/d) for 4 wk on plasma total(More)
Previously we have shown that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs in IRF6 (interferon regulatory factor 6). Here, we use multispecies sequence comparisons to identify a common SNP (rs642961, G>A) in a newly identified IRF6 enhancer. The A allele is significantly overtransmitted (P = 1 x 10(-11)) in(More)