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A soluble α-synuclein construct forms a dynamic tetramer
A heterologously expressed form of the human Parkinson disease-associated protein α-synuclein with a 10-residue N-terminal extension is shown to form a stable tetramer in the absence of lipidExpand
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Bone recognition mechanism of porcine osteocalcin from crystal structure
Osteocalcin is the most abundant noncollagenous protein in bone, and its concentration in serum is closely linked to bone metabolism and serves as a biological marker for the clinical assessment ofExpand
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Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises >1% of total brain protein but is almost absent from other tissues [Wilkinson, K. D., et al. (1989) Science 246, 670-673]. Mutations inExpand
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Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens.
N-Acyl-l-homoserine lactone (AHL) mediated quorum-sensing regulates virulence factor production in a variety of Gram-negative bacteria. Proteins capable of degrading these autoinducers have beenExpand
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Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT
Significance GabR is a member of the MocR/GabR subfamily of the GntR family of bacterial transcription regulators. It regulates the metabolism of γ-aminobutyric acid, an important nitrogen and carbonExpand
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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein
Significance The aggregation of α-synuclein (aSyn) is a pathological hallmark of Parkinson’s disease. Here we show that the enzymatic component of the innate inflammation system, known as caspase-1,Expand
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Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain
Significance Mutations in the gene encoding for leucine-rich-repeat kinase 2 (LRRK2) are a common cause of Parkinson disease (PD). To understand how LRRK2 causes PD, we need to understand its normalExpand
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Reducing C-terminal truncation mitigates synucleinopathy and neurodegeneration in a transgenic model of multiple system atrophy
Significance Multiple system atrophy (MSA) is a fatal neurodegenerative disorder associated with the accumulation of alpha-synuclein (α-syn) aggregates in oligodendrocytes. There is currently noExpand
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Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase
The identification of hot spots, i.e., binding regions that contribute substantially to the free energy of ligand binding, is a critical step for structure-based drug design. Expand
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Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation*
Background: Whether RPL11 directly binds to the zinc finger domain of MDM2 still remains elusive. Results: Mutations of RPL11 or the zinc finger of MDM2 impair the ability of RPL11 to inactivate MDM2Expand
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