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Differential Expression of the RANKL/RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer
Background Human non-small cell lung cancer (NSCLC) patients exhibit a high propensity to develop skeletal metastasis, resulting in excessive osteolytic activity. The RANKL/RANK/OPG system, whichExpand
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Antimicrobial Resistance and Serotypes of Nasopharyngeal Strains of Streptococcus pneumoniae in Chinese Children with Acute Respiratory Infections
  • K. Yao, X. Shen, +7 authors Y. Yang
  • Medicine
  • The Journal of international medical research
  • 1 March 2007
This prospective, multicentre, nasal carriage study in Chinese children with upper respiratory infection was carried out over the period from 2000 to 2002. Overall, the prevalence of pneumococcalExpand
  • 18
  • 2
Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro
Objective To investigate the effects of bortezomib on human osteosarcoma cells from the HOS cell line, and the underlying associated mechanisms. Methods Viability of HOS cells treated with bortezomibExpand
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Smad3 is the key to transforming growth factor-β1-induced osteoclast differentiation in giant cell tumor of bone
  • Z. Lou, Yi Yang, +5 authors W. Guo
  • Medicine, Biology
  • Medical Oncology
  • 21 May 2013
Giant cell tumor (GCT) of bone is a benign but locally aggressive neoplasm of bone. However, molecular mechanisms underlying osteolysis in GCT have not been deeply understood. The aim of this studyExpand
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Prognostic significance of cyclooxygenase-2 in osteosarcoma: a meta-analysis
Published studies researching the prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with osteosarcoma are inconclusive and heterogeneous. We conducted a meta-analysis toExpand
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EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells
Ewing sarcoma (ES) is the most common malignant bone tumor in children and young adults. It is characterized by chromosomal translocations fusing the EWS gene with an ETS oncogene, most frequentlyExpand
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Resistance of Haemophilus influenzae Isolates in Children Under 5 Years Old with Acute Respiratory Infections in China between 2000 and 2002
  • X. Shen, Q. Lu, +7 authors Y. Yang
  • Medicine
  • The Journal of international medical research
  • 1 July 2007
This prospective, three-centre study tested for antimicrobial susceptibility in 898 isolates of Haemophilus influenzae between 2000 and 2002 in Chinese children aged under 5 years with acute upperExpand
  • 6
MicroRNA-34b promotes proliferation, migration and invasion of Ewing's sarcoma cells by downregulating Notch1
Ewing's sarcoma is the second most frequent bone and soft tissue sarcoma, which is commonly driven by the Ewing's sarcoma breakpoint region 1-friend leukemia integration 1 transcription factorExpand
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