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Early clinical studies suggested that infiltrating mast cells could be associated with a poor outcome in bladder cancer (BCa) patients. The mechanisms of how mast cells influence the BCa progression, however, are unclear. Using the human clinical BCa sample survey and in vitro co-culture systems, we found BCa cells could recruit more mast cells than the(More)
Mutational inactivation of the VHL tumor suppressor plays key roles in the development of renal cell carcinoma (RCC), and mutated VHL-mediated VEGF induction has become the main target for the current RCC therapy. Here we identified a signal pathway of VEGF induction by androgen receptor (AR)/miRNA-145 as a new target to suppress RCC progression. Mechanism(More)
OBJECTIVE To find the potential micro-RNA (miRNA) that could determine the fate of prostate cancer stem cells. MATERIALS AND METHODS We compared miRNA expression between our purified CD133+ prostatic cancer stem cells (PCSCs) and CD133- cells. Sphere formation assay and matrigel-based cell invasion assay were applied to determine the stemness of CD133+(More)
By means of high-temperature optical microscopy (HTOM), a 60 °C gap in initial melting temperature between two YBa₂Cu₃O(x) (Y123) thin films was found in situ. Using these two films as seeds, liquid phase epitaxy (LPE) dipping experiments showed the same tendency in the melting behaviour. The in-plane orientation was detected by x-ray diffraction (XRD) pole(More)
OBJECTIVE To investigate the effect of postoperative restrictive fluid management by ensuring adequate tissue perfusion on the recovery of gastrointestinal function after elective colonic resection. METHODS Thirty patients suffered with elective colonic resection, after 6 hours of anesthesia recovery, were randomly divided into restrictive fluid(More)
OBJECTIVE To investigate the value of bioreactance-based passive leg raising (PLR) test predicting fluid responsiveness of elderly patients with sepsis. METHODS This prospective and self-controlled clinical study included 31 elderly patients with sepsis in the Department of Intensive Care Medicine of Zhejiang Hospital. Hemodynamic parameters including(More)
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