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Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression
TLDR
The results implicate correlated activity between the cortex and the striatum, especially the nucleus accumbens core and the basolateral amygdala, in the generation of a conditioned motivated state that may promote excessive food intake. Expand
Brain Fatty Acid Binding Protein (Fabp7) Is Diurnally Regulated in Astrocytes and Hippocampal Granule Cell Precursors in Adult Rodent Brain
TLDR
Brain fatty acid binding protein (Fabp7), which is important in early nervous system development, is expressed in astrocytes and neuronal cell precursors in mature brain, and RNA analysis revealed that Fabp7 mRNA levels were elevated during the light period and lower during dark in brain regions involved in sleep and activity mechanisms. Expand
Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression
TLDR
Whether intra-Acb amylin signaling modulates prepulse inhibition (PPI), a measure of sensorimotor gating deficient in several illnesses including schizophrenia, is investigated and AMY1-R may be a potential target for the development of putative antipsychotics or adjunct treatments that oppose metabolic side effects of current medications. Expand
The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain
TLDR
It is reported here that acute nicotine (0.4 mg/kg), but not cocaine or exposure to a novel environment, induces the expression of the dendritically targeted, corticolimbic mRNA Dendrin in specific regions of adolescent brain. Expand
Quantitative Mass Spectrometry Reveals Food Intake-Induced Neuropeptide Level Changes in Rat Brain: Functional Assessment of Selected Neuropeptides as Feeding Regulators*
TLDR
This study demonstrated neuropeptidomic changes in response to food intake in the rat NAc and other key brain regions, suggesting the potential use of these peptides as therapeutics for eating disorders. Expand
Mutations in the rat myelin basic protein gene are associated with specific alterations in other myelin gene expression
TLDR
A marked reduction in all major myelin proteins and differences in their intracellular distribution was revealed and Quantitation of mRNA levels indicated that decreases in PLP and DM20 were a result of changes in mRNA levels but detected no change in other myelin gene transcripts. Expand
Upregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss
TLDR
A novel set of sleep deprivation-induced transcriptional changes in reward-modulatory peptide systems are revealed, which are dissociable from the energy-balance perturbations of sleep loss or the potentially stressful effects of the forced-locomotion procedure. Expand