Queena Hwang

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Degradation of collagen is required for the physiological remodelling of connective tissues during growth and development, as well as in wound healing, inflammatory diseases, and cancer cell invasion. In remodelling adult tissues, degradation of collagen occurs primarily through a phagocytic pathway. While various steps in this pathway have been(More)
A new derivatizing reagent, butylisothiocyanate (BITC), reacts quantitatively with the 22 standard amino acids and the amino acids in the acid hydrolysate of food and the protein standard, bovine serum albumin (BSA), at 40 degrees C for 30 min to yield butylthiocarbamyl (BTC) amino acids. The sensitivity of BTC-amino acid was similar to phenylthiocarbamyl(More)
A recent model for activation of the zymogen form of matrix metalloproteinase 2 (MMP-2, also known as gelatinase A) has suggested that interactions between the SIBLING protein bone sialoprotein (BSP) and MMP-2 leads to conformational change in MMP-2 that initiates the conversion of the pro-enzyme into a catalytically active form. This model is particularly(More)
The hypothesis was evaluated that neurons within the retrofacial nucleus of medulla integrate afferent stimuli from the central chemoreceptors. In decerebrate, vagotomized, paralyzed and ventilated cats, activity of the phrenic nerve was monitored. Peak integrated phrenic activity increased in hypercapnia; the frequency of phrenic bursts typically declined(More)
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