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The pathways by which oncogenes, such as MLL-AF9, initiate transformation and leukemia in humans and mice are incompletely defined. In a study of target cells and oncogene dosage, we found that Mll-AF9, when under endogenous regulatory control, efficiently transformed LSK (Lin(-)Sca1(+)c-kit(+)) stem cells, while committed granulocyte-monocyte progenitors(More)
In this paper, we propose the first real time rumor debunking algorithm for Twitter. We use cues from 'wisdom of the crowds', that is, the aggregate 'common sense' and investigative journalism of Twitter users. We concentrate on identification of a rumor as an event that may comprise of one or more conflicting microblogs. We continue monitoring the rumor(More)
The 2 most frequent human MLL hematopoietic malignancies involve either AF4 or AF9 as fusion partners; each has distinct biology but the role of the fusion partner is not clear. We produced Mll-AF4 knock-in (KI) mice by homologous recombination in embryonic stem cells and compared them with Mll-AF9 KI mice. Young Mll-AF4 mice had lymphoid and myeloid(More)
However, many text mining applications do not have adequate natural language processing ability beyond simple keyword indexing, and as a result, there are too many textual elements (words) included in the analysis. We argue that noun phrases as textual elements are better suited for text mining and could provide more discriminating power, than single words.(More)
PURPOSE We conducted studies to evaluate the hypothesis that FLT3 is a client of heat shock protein (Hsp) 90 and inhibitors of Hsp90 may be useful for therapy of leukemia. EXPERIMENTAL DESIGN The effects of the Hsp90-inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on cell growth, expression of signal transduction kinases, apoptosis, FLT3(More)
Effectiveness and efficiency of searching and returned results presentation is the key to a search engine. Before downloading and examining the document text, users usually first judge the relevance of a return hit to the query by looking at document metadata presented in the return result. However, the metadata coming with the return hit is usually not(More)
Most search engines display some document metadata, such as title, snippet and URL, in conjunction with the returned hits to aid users in determining documents. However, metadata is usually fragmented pieces of information that, even when combined, does not provide an overview of a returned document. In this paper, we propose a mechanism of enriching(More)
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear. In the human leukemia cell lines - RS4;11 and(More)
We report a keyphrase identification program (KIP), which uses sample human keyphrases and then learns to identify additional new keyphrases. KIP first populates its database using manually identified keyphrases; each keyphrase is preprocessed and assigned an initial weight. It then extracts noun phrases from documents. All noun phrases will be assigned a(More)