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Proteomics analyses were performed on the brains of wild-type (WT) controls and an Alzheimer's disease (AD) mouse model, APP/PS-1 human double mutant knock-in mice. Mice were given either drinking water or water supplemented with N-acetylcysteine (NAC) (2 mg/kg body weight) for a period of five months. The time periods of treatment correspond to ages prior(More)
Tricyclodecan-9-yl-xanthogenate (D609) has in vivo and in vitro antioxidant properties. D609 mimics glutathione (GSH) and has a free thiol group, which upon oxidation forms a disulfide. The resulting dixanthate is a substrate for glutathione reductase, regenerating D609. Recent studies have also shown that D609 protects brain in vivo and neuronal cultures(More)
Alzheimer's disease (AD) is the most prevalent form of dementia among the elderly. Although the underlying cause has yet to be established, numerous data have shown that oxidative stress is implicated in AD as well as in preclinical stages of AD, such as mild cognitive impairment (MCI). The oxidative stress observed in brains of subjects with AD and MCI may(More)
Autonomous obstacle avoidance technology is the best way to embody the feature of robot strong intelligence in intelligent robot navigation system. In order to solve the problem of autonomous obstacle avoidance of mobile robot, an intelligent model is used in this paper. Adopting multi-sensor data fusion technology and obstacle avoidance algorithm based on(More)
—Control channel model parameters of adaptive filter feedforward control for piezoelectric smart flexible structures should be predicted, as not only they are the key factors of system stability and control effect but also they have immediate impacts on system convergence and the validity of control strategy. This paper takes the piezoelectric flexible(More)
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