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Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates
TLDR
‘m6A editing’ is reported, a powerful approach that enables m6A installation and erasure from cellular RNAs without changing the primary sequence and facilitates mechanistic understanding of epitranscriptome.
Decoding mRNA translatability and stability from the 5′ UTR
TLDR
Massively parallel reporter assays from a synthetic mRNA library identify sequence features of 5′ UTRs that control mRNA translatability and reveal ribosome-dependent and ribosomesome-independent mRNA-surveillance pathways.
Decoding mRNA translatability and stability from 5’UTR
Precise control of protein synthesis by engineering sequence elements in 5’ untranslated region (5’UTR) remains a fundamental challenge. To accelerate our understanding of cis-regulatory code
A heat shock–responsive lncRNA Heat acts as a HSF1-directed transcriptional brake via m6A modification
TLDR
A heat shock–inducible long noncoding RNA, Heat, is reported in mouse cells that acts as a transcriptional brake to restrain stress gene expression during the recovery phase and reveals a crucial role of nuclear epitranscriptome in the transcriptional regulation of heat shock response.