Quanhong Sun

Learn More
The high mortality rate of lung cancer is largely due to the spread of disease to other organs. However, the molecular changes driving lung cancer invasion and metastasis remain unclear. In this study, we identified fibulin-5, a vascular ligand for integrin receptors, as a suppressor of lung cancer invasion and metastasis. Fibulin-5 was silenced by promoter(More)
Head and neck squamous cell carcinoma (HNSCC) ranks the eighth most common cancer worldwide. The patients often present with advanced disease, which responds poorly to chemoradiation therapy. PUMA is a BH3-only Bcl-2 family protein and a p53 target that is required for apoptosis induced by p53 and various chemotherapeutic agents. In this study, we found(More)
Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents. The mechanisms underlying the responsiveness to most agents targeting cancer specific survival pathways are still poorly understood but critical for their clinical application. In this study, we(More)
Aiming at the problems in the management and sharing research of antique information, this paper discussed the necessity to build antique information distributed data warehouse. The data warehouse architecture and the multidi-mensional data model were put forward, by usingonline analysis processing (OLAP) the multidimensional analysis of antique distributed(More)
PURPOSE Overexpression of inhibitors of apoptosis proteins (IAP) contributes to therapeutic resistance. Second mitochondria-derived activator of caspase (Smac) promotes caspase activation by binding to IAPs upon release from the mitochondria. IAP antagonists, also called SMAC mimetics, are promising anticancer agents modeled after this mechanism. We(More)
Aiming at the current situation of information management and sharing in all Fossil Power Plant, this paper outlines the basic concepts of DW, introduces a method using Data Warehouse (DW) technology in the platform. This paper has analyzed subjects of DW in Fossil Power. Basing on DW, the model has been developed with dimensional modeling technology, a(More)
Purpose: Overexpression of inhibitors of apoptosis proteins (IAP) contributes to therapeutic resistance. Second mitochondria-derived activator of caspase (Smac) promotes caspase activation by binding to IAPs upon release from the mitochondria. IAP antagonists, also called SMAC mimetics, are promising anticancer agents modeled after this mechanism. We(More)
  • 1