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BACKGROUND Diarrhea associated with rotavirus and Escherichia coli is one of the major gastrointestinal problems faced by human infants. Using a piglet model, the authors investigated the protective effectiveness of probiotic feeding against naturally acquired diarrhea in weanlings. METHODS Seventeen piglets were allocated into two groups balanced for(More)
The general safety of immune-enhancing lactic acid bacteria (LAB) strains Lactobacillus rhamnosus HN001 (DR20), Lb. acidophilus HN017, and Bifidobacterium lactis HN019 (DR10) was investigated in a feeding trial. Groups of BALB/c mice were orally administered test LAB strains or the commercial reference strain Lb. acidophilus LA-1 at 2.5 x 10(9), 5 x 10(10)(More)
The probiotic lactic acid bacterium Lactobacillus rhamnosus (strain HN001) is known to stimulate enhanced innate and acquired immune responses in mice, following oral delivery. Here, the ability of HN001 to confer immune enhancement and protection against an oral challenge of Salmonella typhimurium was investigated. HN001-fed and non-probiotic-fed control(More)
Lactic acidosis is a gastrointestinal disorder resulting from the rapid overgrowth of lactic acid-producing bacteria when ruminants are suddenly introduced to grain feed. The present study has investigated the ability of live and killed bacterial vaccines to reduce lactic acidosis in sheep, via a stimulation of specific antibody production against lactic(More)
This study investigated the effects of bovine lactoferrin (BLf) on the growth of different groups of bacteria in vitro. BLf showed a significant inhibitory effect on the growth of selected pathogens but not probiotics. BLf, in combination with probiotics, has the potential to influence the composition of the gut microflora via inhibition of intestinal(More)
Streptococcus bovis is an important lactic acid bacterium in the rumen, which contributes to the development of lactic acidosis. This study was designed to test the efficacy of immunization with S. bovis primed either intramuscularly (i.m.) or intraperitoneally (i.p. ) against lactic acidosis. Forty-five wethers were allocated to three treatment groups. Two(More)
OBJECTIVE To determine efficacy of vaccines incorporating QuilA, alum, dextran combined with mineral oil, or Freund adjuvant for immunization of feedlot cattle against Streptococcus bovis and Lactobacillus spp. ANIMALS 24 steers housed under feedlot conditions. PROCEDURE Steers were randomly assigned to 4 experimental groups and a control group. Animals(More)
The protective effects of the probiotic Bifidobacterium lactis HN019 against Escherichia coli O157:H7 were investigated in murine challenge infection models. BALB/c or C57BL/6 mice were fed milk-based diets supplemented with B. lactis HN019 (3 × 108 cfu/g) for 7 days prior to and following oral challenge with E. coli O157:H7. Behavioral parameters(More)
Lactoferrin is an iron-binding glycoprotein that exhibits a range of health benefits including immune regulation and disease prevention derived from its structural properties. The present study employed immune cell models and a colon epithelial cell model to investigate the protective effects of bovine lactoferrin (BLf) on both immune cells and colon(More)
The present study was designed to investigate the efficacy of control of lactic acidosis by immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus. Ten steers were allocated to two treatment groups. One group was immunised with a vaccine containing S. bovis (strain Sb-5) and Lactobacillus (LB-27) cells, and the other was(More)