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In component-based software engineering, software systems are mainly constructed based on reusable components, such as third-party components and in-house built components. Hence, system quality depends on the quality of the involved components. Any change of a component, it must be re-tested at the unit level, and re-integrated to form component-based(More)
Purpose:UGT1A1*28 confers a higher risk of toxicity in patients treated with irinotecan. Patients with *1/*1 and *1/*28 genotypes might tolerate higher than standard doses of irinotecan. We aimed to identify the MTD of irinotecan in patients with metastatic colorectal cancer (mCRC) with *1/*1 and *1/*28 genotypes treated with FOLFIRI plus bevacizumab, and(More)
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