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BACKGROUND MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular diseases such as cardioprotection of murine hearts after myocardial infarction via miR-92a inhibitors. Because the functional benefits of miR-92a inhibitors in(More)
Heart failure due to myocardial infarction is a major cause of mortality. The microRNA (miR) family let-7 is expressed during embryonic development and is up-regulated in differentiated cells. The aim of this study was to study the role of let-7 after acute myocardial infarction (AMI). We designed an antimiR to inhibit the highest expressed members of the(More)
This paper analyzes, and thus reveals the structure of the stable invariant subspace of the related Hamiltonian matrix arising from the measurement feedback H∞-control problem. Using this, it presents another method for the verification of the admissibility of the controller derived by Doyle et al. in 1989. The method not only eliminates unnecessary(More)
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