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Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We aligned the short reads onto the NCBI human reference genome to 99.97% coverage, and guided by the reference genome, we used uniquely mapped reads to assemble a high-quality(More)
Delineating regions of interest (ROIs) on each phase of four-dimensional (4D) computed tomography (CT) images is an essential step for 4D radiotherapy. The requirement of manual phase-by-phase contouring prohibits the routine use of 4D radiotherapy. This paper develops an automatic re-contouring algorithm that combines techniques of deformable registration(More)
As applications such as Apple Siri, Google Now, Microsoft Cortana, and Amazon Echo continue to gain traction, web-service companies are adopting large deep neural networks (DNN) for machine learning challenges such as image processing, speech recognition, natural language processing, among others. A number of open questions arise as to the design of a(More)
A script-based attack framework is a new type of cyber-attack tool written in scripting languages. It carries various attack scripts targeting vulnerabilities across different systems. It also supports fast development of new attack scripts that can even exploit zero-day vulnerabilities. Such mechanisms pose a big challenge to the defense side since(More)
DNA methylation plays an important role in biological processes in human health and disease. Recent technological advances allow unbiased whole-genome DNA methylation (methylome) analysis to be carried out on human cells. Using whole-genome bisulfite sequencing at 24.7-fold coverage (12.3-fold per strand), we report a comprehensive (92.62%) methylome and(More)
—Hadoop is seriously limited by its MapReduce scheduler which does not scale well in heterogeneous environment. Heterogenous environment is characterized by various devices which vary greatly with respect to the capacities of computation and communication, architectures, memorizes and power. As an important extension of Hadoop, LATE MapRe-duce scheduling(More)
TrustZone-based Real-time Kernel Protection (TZ-RKP) is a novel system that provides real-time protection of the OS kernel using the ARM TrustZone secure world. TZ-RKP is more secure than current approaches that use hypervisors to host kernel protection tools. Although hypervisors provide privilege and isolation, they face fundamental security challenges(More)