Qiwen Yang

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OBJECTIVE 5-Fluorouracil (5-Fu) has been widely used as a first-line drug for colorectal cancer (CRC) treatment but limited by drug resistance and severe toxicity. The chemo-sensitizers that augment its efficiency and overcome its limitation are urgently needed. Gypenosides (Gyp), the main components from Gynostemma pentaphyllum (Thunb.) Makino, has shown(More)
Extremal optimization (EO) is a phenomenon-mimicking algorithm inspired by the Bak-Sneppen model of self-organized criticality from the field of statistical physics. The canonical EO works on a single solution and only employs mutation operator, which is inclined to prematurely converge to local optima. In this paper, a population-based extremal(More)
BACKGROUND Published information regarding the clinical characteristics, laboratory findings, and outcomes of patients with Mycobacterium tuberculosis (MTB) blood stream infection (BSI) is limited. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with MTB BSI. METHODS All patients diagnosed(More)
There are challenges in viridans group streptococci (VGS) identification especially for the mitis group. Few studies have investigated the performance of MALDI-TOF MS system in VGS identification. Using 16S rRNA gene and gyrB gene sequencing as a gold standard, the performance of two MALDI-TOF MS instruments in the identification of 181 VGS clinical(More)
BACKGROUND Nontuberculous Mycobacterium (NTM) bloodstream infection (BSI) is relatively rare. We aimed in this study to evaluate the clinical characteristics, laboratory evaluation, and outcomes of patients with NTM BSI. METHODS We retrospectively reviewed the clinical records of inpatients with NTM BSI at our institution between January 2008 and January(More)