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BACKGROUND Observational and experimental studies have thus far been unable to resolve whether the CYBA C242T polymorphism is associated with coronary artery disease (CAD). Therefore, we undertook a comprehensive meta-analysis to more precisely evaluate the influence of this polymorphism on CAD and potential biases. METHODS We screened MEDLINE, Embase,(More)
BACKGROUND We sought to explore the association of variant rs1333049 on chromosome 9p21.3 with coronary artery disease (CAD) and angiographic plaque progression in non-diabetic and type 2 diabetic patients. METHODS Genotyping and quantitative coronary angiography (QCA) were performed in 2046 Chinese Han patients (1012 diabetic cases) undergoing coronary(More)
BACKGROUND The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, and nephropathy and coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). METHODS Plasma levels of OPN, N-half OPN, and high-sensitivity C-reactive protein (hsCRP) were(More)
BACKGROUND The selectins play important roles in the inflammatory process of coronary artery disease (CAD) and myocardial infarction (MI). Previous studies have shown ambiguous findings regarding a possible association between the selectin genes and CAD. The E-selectin Ser128Arg polymorphism and the P-selectin Thr715Pro polymorphism have been investigated(More)
Recent randomized controlled trials have challenged the concept that increased high density lipoprotein cholesterol (HDL-C) levels are associated with coronary artery disease (CAD) risk reduction. The causal role of HDL-C in the development of atherosclerosis remains unclear. To increase precision and to minimize residual confounding, we exploited the(More)
This cross-sectional study tested the hypothesis that decreased serum levels of tetranectin (TN), a regulator of the fibrinolysis and proteolytic system, is associated with the presence and severity of CAD. We conducted a systematic serological and immunohistochemical (IHC) analysis to respectively compare the TN levels in serum and artery samples in CAD(More)
AIMS This study investigated whether S100A4 plays a potential role in the formation of thoracic aortic aneurysm (TAA). METHODS AND RESULTS The thoracic aortas of male Sprague-Dawley rats were exposed to 0.5 M CaCl2 or normal saline (NaCl). Animals were euthanized at specified time-points (2, 4, and 10 weeks post-TAA induction). The treated aortic segments(More)
OBJECTIVE To observe the effects of ZMS on learning and memory ability and on brain choline acetyltransferase activity. METHODS A single intraperitoneal injection of scopolamine was used to establish a dementia mouse model. The learning and memory ability was detected by step-through and sted-down tests. And the choline acetyltransferase activity in brain(More)
Whether serum calcium is associated with heart systolic function in patients with established coronary artery disease (CAD) and acute myocardial infarction (AMI) remains to be elucidated. This study is aimed to assess the association between serum calcium and left ventricular systolic dysfunction in a Chinese population of CAD. The cross-sectional study(More)
Pro-inflammatory mediators are identified in patients with heart failure (HF), some of which may be used as biomarkers with diagnostic or prognostic value. As an additional ligand of Colony Stimulating Factor-1 Receptor (CSF-1R), interleukin-34 (IL-34) has been identified as a pro-inflammatory cytokine participating in chronic heart failure (CHF). However,(More)