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Asymmetric [3 + 2] Cycloaddition of 2,3-Butadienoates with Electron-Deficient Olefins Catalyzed by Novel Chiral 2,5-Dialkyl-7-phenyl-7- phosphabicyclo[2.2.1]heptanes
Among the reported methods, [3 + 2] cycloaddition has the advantage of forming multiple bonds although issues of chemo-, regio-, diastereo-, and enantioselectivity must be resolved if the process isExpand
Asymmetric Formation of Quaternary Carbon Centers Catalyzed by Novel Chiral 2,5-Dialkyl-7-phenyl-7-phosphabicyclo[2.2.1]heptanes
Many important biologically active compounds contain quaternary carbon centers. Efficient asymmetric syntheses of these compounds represent a significant challenge in organic chemistry.1 SomeExpand
Highly Enantioselective Hydrogenation of Cyclic Enamides Catalyzed by a Rh-PennPhos Catalyst.
This facile synthesis of enamides combined with an efficient asymmetric hydrogenation step provides a practical protocol for the synthesis of chiral amines from ketones, and high enantioselectivities have been achieved for the hydrogenation of acyclic enamide with a Rh-BICP catalyst. Expand
A New Chiral Bis(oxazolinylmethyl)amine Ligand for Ru-Catalyzed Asymmetric Transfer Hydrogenation of Ketones
Asymmetric catalytic transfer hydrogenation using 2-propanol as a hydrogen source offers an attractive route for reducing simple unfunctionalized ketones to chiral alcohols. 1 The reaction usesExpand
Highly Enantioselective Hydrogenation of Simple Ketones Catalyzed by a Rh-PennPhos Complex.
Even alkyl methyl ketones undergo asymmetric hydrogenation with high enantioselectivity when a rhodium complex of the conformationally rigid chiral ligand 1 (Me-PennPhos; R=CH3 ) is used as theExpand
Highly effective NPN-type tridentate ligands for asymmetric transfer hydrogenation of ketones
Abstract New chiral NPN-type tridentate ligands containing two oxazoline rings and one phosphine have been synthesized, and their Ru(II) complexes show high reactivity and enantioselectivity inExpand
Highly Enantioselective Hydrogenation of Cyclic Enol Acetates Catalyzed by a Rh-PennPhos Complex.
The electron-rich and conformationally rigid (R,S,R,S)-Me-PennPhos ligand (shown schematically) appears to chelate rhodium and form well-defined chiral pockets. This allows, for example, efficientExpand
Synthesis of (1R,1R′)-2,6-bis[1-(diphenylphosphino)ethyl]pyridine and its application in asymmetric transfer hydrogenation
Abstract A C 2 symmetric tridentate ligand, (1R, 1R′) 2,6-Bis[1-(diphenylphosphino)ethyl]pyridine, has been synthesized in enantiomerically pure form. A practical method to synthesize a variety ofExpand
Highly Enantioselective Rh-Catalyzed Hydrogenations with a New Chiral 1,4-Bisphosphine Containing a Cyclic Backbone
The design and synthesis of chiral phosphine ligands have played a significant role in the development of transition metal catalyzed asymmetric reactions.1 Over 1000 chiral bisphosphines2 have beenExpand
Abstract New chiral ligands 3 and 5 have been synthesized. Their Ru(II) complexes are effective catalysts for transfer hydrogenation of both aryl alkyl and dialkyl ketones (with ee's up to 79.5%).