Qinlan Guan

Learn More
BACKGROUND Studies have found that the IL-23/Th17 pathway plays an important role in the pathogenesis of atopic dermatitis (AD) and severe and steroid-resistant asthma. Targeting IL-23/Th17 pathway with monoclonal antibodies (mAb) has been successful in the reduction of skin and airway inflammation in animal models. However, the mAb has a short half-life,(More)
UNLABELLED In this report, a glycoside hydrolase 13 family pullulanase gene (Tk0977) was cloned from a thermophilic anaerobic archaeon Thermococcus kodakarensis KOD1 (Pul-Tk). Pul-Tk encodes a protein of 765 amino acids including a putative 22-residue signal peptide. The protein has four consensus motives and a catalytic triad of glycoside hydrolase 13(More)
BACKGROUND Allergic reactions to mosquito bites are an increasing clinical concern. Due to the lack of availability of mosquito salivary allergens, they are underdiagnosed. Here, we reported a newly cloned mosquito Aedes (Ae.) aegypti salivary allergen. METHODS A cDNA encoding a 30-kDa Ae. aegypti salivary protein, designated Aed a 3, was isolated from an(More)
Antagonistic activities against Verticillium dahliae were screened in sixty endophytic bacteria isolated from root nodules of Sophora alopecuroides by plate spreading, plate confrontational culture and examining the antifungal activity of extracellular products methods. The results showed that inhibitory rate of more than half of the 60 studied strains is(More)
  • 1