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OBJECTIVE To study the expression of PTEN, p53 and epidermal growth factor receptor (EGFR) in the molecular subtypes of breast carcinoma and to evaluate the correlations with triple-negative breast cancer.
 METHODS Immunohistochemical MaxVision(TM) method was used to detect the expression of PTEN, p53, EGFR, estrogen receptor (ER), progesterone receptor(More)
BACKGROUND Our previous studies showed a down-regulation of GRIM-19 in primary human cervical cancers, and restoration of GRIM-19 induced tumor regression. The induction of tumor suppressor protein p53 ubiquitination and degradation by E6 oncoportein of high risk-HPV through forming a stable complex with E6AP is considered as a critical mechanism for(More)
BACKGROUND The changes of hemodynamics and drug concentration distribution caused by the implantation of drug eluting stents (DESs) in curved vessels have significant effects on In-Stent Restenosis. METHODS A 3D virtual stent with 90° curvature was modelled and the distribution of wall shear stress (WSS) and drug concentration in this model were(More)
With reduced environmental impact becoming an increasingly important benefit of the rail transportation mode, continual improvement in efficiency and reduced energy consumption has become a major concern to rail transit operators. For electrified rail transit operations, regenerative braking is one practical way for saving energy because it enables the(More)
Railway systems may be interrupted by unforeseen events that require quick replanning to a feasible new schedule. This paper deals with the train rescheduling problem on double-track lines. The rescheduling problem is regarded as a conflict detection and resolution procedure. Timed Colored Petri nets are adopted to model the railway system: places represent(More)
Foamed mortar with a density of 1300 kg/m 3 was prepared. In the initial laboratory trials, water-to-cement (w/c) ratios ranging from 0.54 to 0.64 were tested to determine the optimal value for foamed mortar corresponding to the highest compressive strength without compromising its fresh state properties. With the obtained optimal w/c ratio of 0.56, two(More)
High telomerase activity promotes tumor growth by stabilizing damaged chromosomes and their mitotic replication. Overactivation of telomerase activity has been reported in cervical cancer, a malignancy caused by high-risk human papillomaviruses (HR-HPVs). The HR-HPV E6 can activate hTERT promoter by interacting with E6AP or other binding proteins and by(More)
In this paper, the fundamental characteristics of cyclostationary signal are investigated. Firstly, through analyzing the cyclostationarity of some typical satellite communication signals (e.g. MPSK, MSK and QAM signals), the guidelines to blindly detect satellite communication signals are obtained. Then the simulation of the above signals' cyclic spectrum(More)
Alteration of the careful balance of the ratio of Th1/Th2 cell subsets impacts immune function and plays an important role in the pathogenesis of asthma. There is little research on the impact of changes on the balance of the regulatory T (Treg)/Th17 subset ratio and its possible repercussions for asthma. This investigation used a murine model of asthma to(More)