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Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
Type I interferon (IFN) serves as the first line of defense against invading pathogens. Inhibition of IFN-triggered signaling cascade by Zika virus (ZIKV) plays a critical role for ZIKV to evadeExpand
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TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1
Type I interferon (IFN) is an important component of antiviral innate immune signaling mediated by viral DNA and RNA recognition by the DNA sensor cGAS and RNA sensors RIG-I and MDA5. Activation ofExpand
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Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1‐caspase‐1 axis
Viral infection triggers host innate immune responses, which primarily include the activation of type I interferon (IFN) signaling and inflammasomes. Here, we report that Zika virus (ZIKV) infectionExpand
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Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro
[This corrects the article DOI: 10.1038/celldisc.2017.6.].
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LRRC25 inhibits type I IFN signaling by targeting ISG15‐associated RIG‐I for autophagic degradation
The RIG‐I‐like receptors (RLRs) are critical for protection against RNA virus infection, and their activities must be stringently controlled to maintain immune homeostasis. Here, we report thatExpand
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Fluoride-driven ‘turn on’ ESPT in the binding with a novel benzimidazole-based sensor
Summary A novel fluorescence sensor (BIP) bearing NH and OH subunits displayed a highly selective and sensitive recognition property for fluoride over other anions. Fluoride-driven ESPT, poorly usedExpand
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Programmed cell death is responsible for replaceable bud senescence in chestnut (Castanea mollissima BL.)
AbstractIn the chestnut “replaceable bud” cultivar ‘Tima zhenzhu’, the auxiliary bud formed on the fruiting branch dies after fruiting, giving rise to a morphology more suitable than the wild type’sExpand
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An IoT-Oriented data placement method with privacy preservation in cloud environment
TLDR
An IoT-oriented data placement method with privacy preservation, based on the Non-dominated Sorting Genetic Algorithm II (NSGA-II), is designed in this paper. Expand
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Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses
Deubiquitinase family proteins are broadly involved in modulating antiviral response through dynamic and diverse mechanisms. The innate immune response conferred by type I interferons is essentialExpand
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Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression
Stratified multisite ubiquitination of RIG-I provides a robust and optimal control of innate antiviral responses. The activation of retinoic acid–inducible gene I (RIG-I), an indispensable viral RNAExpand
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