Qingwen Jin

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superoxide dismutase 1 gene is associated with slow motor neuron progression and mild cognitive impairment in a Chinese family with amyotrophic lateral sclerosis Most patients with amyotrophic lateral sclerosis (ALS) have mild cognitive impairment. 1 A familial ALS (fALS) case carrying a SOD1 missense mutation with non-executive cognitive impairment was(More)
Most bamboo forests grow in humid climates in low-latitude tropical or subtropical monsoon areas, and they are generally located in hilly areas. Bamboo trunks are very straight and smooth, which means that bamboo forests have low structural diversity. These features are beneficial to synthetic aperture radar (SAR) microwave penetration and they provide(More)
BACKGROUND Insertion of T4 lysozyme (T4L) into the GPCR successfully enhanced GPCR protein stability and solubilization. However, the biological functions of the recombinant GPCR protein have not been analyzed. METHODS We engineered the CCR5-T4L mutant and expressed and purified the soluble recombinant protein using an E.coli expression system. The(More)
Recent studies have identified mutations in the dynein heavy chain gene (DYNC1H1), which lead to 2 closely related human motor neuropathies: a dominant spinal muscular atrophy with lower extremity predominance (SMALED) and axonal Charcot-Marie-Tooth (CMT) disease.(1,2) We describe the identification of a novel mutation (p.G807S) in DYNC1H1 as the cause of(More)
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