Qingsheng Kong

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The nicotinamide adenine dinucleotide-dependent protein deacetylase silent information regulator 2 (Sir2) regulates cellular lifespan in several organisms. Histone deacetylase 4 (HDAC4) belongs to the class IIa group of HDACs; this class of HDACs is composed of proteins that are important regulators of gene expression that control pleiotropic cellular(More)
Load-balancing problem, which covers a large area in engineering fields where several parallel entities share the same load on the systems, is studied. A control technique for solving such problem, called differences control technique (DsCT), is investigated. Two types of systems whose parallel entities can be approximated respectively as an integral and a(More)
Histone acetylation is a major mechanism of chromatin remodeling, contributing to epigenetic regulation of gene transcription. Histone deacetylases (HDACs) are involved in both physiological and pathological conditions by regulating the status of histone acetylation. Although histone deacetylase 4 (HDAC4), a member of the HDAC family, may lack HDAC(More)
Estrogen receptor beta (ERβ) plays a role in prostate carcinogenesis. In this study, we investigated the effects of ERβ gene silencing in PC3 androgen-independent prostate cancer cells. PC3 cells were transfected with vector alone, scrambled shRNA vector, vector encoding ERβ-targeting shRNA (shERβ), or shERβ followed by addition of PD98059, a(More)
A series of compounds, naphthalimide derivatives containing sulfoxide or sulfone substituents, were easily synthesized and characterized, which can be used for detection of glutathione. The detailed spectral studies demonstrated that the compounds displayed high selectivity for glutathione over cysteine, homocysteine and other biological molecules. Further(More)
Ureter reconstruction is still a tough task for urologist. Cell-based tissue engineering serves a better technique for patients with long segments of ureter defect who need ureter reconstruction. In this study, we sought to evaluate the differentiation potential of adipose derived stem cells (ADSCs) into urothelial lineage and smooth muscle lineage and to(More)
The metalloprotease lethal factor (LF) from Bacillus anthracis plays a vital role in anthrax toxin action, and thus becomes a target for anti-anthrax therapy. Following the guidelines based on existing metalloprotease inhibitors, we designed a ‘first-generation’ LF inhibitor R9LF-1. This inhibitor was shown to be very stable by itself in a wide range of pH(More)
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