Learn More
  • Jun Wu, Hsin-Pei Shih, Vladimir Vigont, Lori Hrdlicka, Len Diggins, Carol Singh +12 others
  • 2011
Huntington's disease (HD) is a neurodegenerative disorder caused by a polyglutamine expansion within Huntingtin (Htt) protein. In the phenotypic screen we identified a class of quinazoline-derived compounds that delayed a progression of a motor phenotype in transgenic Drosophila HD flies. We found that the store-operated calcium (Ca(2+)) entry (SOC) pathway(More)
  • Kenji Ohba, Koji Ichiyama, Misako Yajima, Nobuhiro Gemma, Masaru Nikaido, Qingqing Wu +5 others
  • 2014
High prevalence of infection with high-risk human papilloma virus (HPV) ranging from 25 to 100% (average 31%) was observed in breast cancer (BC) patients in Singapore using novel DNA chip technology. Early stage of BC demonstrated higher HPV positivity, and BC positive for estrogen receptor (ER) showed significantly higher HPV infection rate. This unique(More)
This study aimed to investigate the in vitro skin permeation and in vivo antineoplastic effect of curcumin by using liposomes as the transdermal drug-delivery system. Soybean phospholipids (SPC), egg yolk phospholipids (EPC), and hydrogenated soybean phospholipids (HSPC) were selected for the preparation of different kinds of phospholipids composed of(More)
This paper considers a wireless powered communication network (WPCN), where multiple users harvest energy from a dedicated power station and then communicate with an information receiving station. Our goal is to investigate the maximum achievable energy efficiency (EE) of the network via joint time allocation and power control while taking into account the(More)
  • Qingqing Wu, Lorie R Blakeley, M Carter Cornwall, Rosalie K Crouch, Barbara N Wiggert, Yiannis Koutalos
  • 2007
Light detection by vertebrate rod photoreceptor outer segments results in the destruction of the visual pigment, rhodopsin, as its retinyl moiety is photoisomerized from 11-cis to all-trans. The regeneration of rhodopsin is necessary for vision and begins with the release of the all-trans retinal and its reduction to all-trans retinol. Retinol is then(More)
—Most of the existing works on energy-efficient wireless communication systems only consider the transmitter (Tx) or the receiver (Rx) side power consumption but not both. Moreover, they often assume the static circuit power consumption. To be more practical, this paper considers the joint Tx and Rx power consumption in multiple-access radio networks, where(More)
BACKGROUND Nanostructured lipid carriers (NLCs) are attractive materials for topical drug delivery, and in a previous study, we demonstrated that NLCs loaded with tripterine enhance its deposition. However, the surface charge of nanoparticles influences percutaneous drug penetration. Therefore, we aimed to evaluate the influence of the surface charge of(More)
PURPOSE To develop nanostructured-lipid carriers (NLCs) coated with cell-penetrating peptides (CPP) for improving the oral bioavailability of tripterine. METHODS We prepared CPP-coated tripterine-loaded NLCs (CT-NLCs) by using a solvent evaporation method, and determined their physical properties. In vitro drug release was determined by using a dialysis(More)