Qingkui Liao

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BACKGROUND AND AIM Multidrug resistance (MDR) compromises the efficacy of chemotherapy. Many approaches have been used to reduce MDR; however, the results are poor. It has been reported that iron deprivation downregulates MDR genes. To investigate the relationship of iron with MDR and early growth response gene-1 (EGR1), we investigated the effect of iron(More)
OBJECTIVE To explore the effect of recombinant human erythropoitin (rhEPO) and T3 on the iron metabolism of K562 cells and its possible mechanism. METHODS With the use of the bone marrow iron stain method, the positive stained cells rate was calculated. Flow cytometry was performed to detect the transferrin receptor (TfR) expression of K562 cells. (More)
OBJECTIVE To explore the gene expression of human telomerase reverse transcriptase (hTERT) in acute leukemia (AL) children and its clinical implication. METHODS Expression of hTERT mRNA was detected in K562 leukemia cell line, 40 acute leukemia children (AL) and 10 healthy subjects by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS(More)
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