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Basic fibroblast growth factor (bFGF) delivery to the brain of animals appears to be an emerging potential therapeutic approach to neurodegenerative diseases, such as Alzheimer's disease (AD). The intranasal route of administration could provide an alternative to intracerebroventricular infusion. A nasal spray of bFGF had been developed previously and the(More)
Fast adaptation of deep neural networks (DNN) is an important research topic in deep learning. In this paper, we have proposed a general adaptation scheme for DNN based on discriminant condition codes, which are directly fed to various layers of a pre-trained DNN through a new set of connection weights. Moreover, we present several training methods to learn(More)
We report applications of language technologies to analyzing historical documents in the Database for the Study of Modern Chinese Thoughts and Literature (DSMCTL). We studied two historical issues with the reported techniques: the conceptu-alization of " 華人 " and the attempt to institute constitutional monarchy in the late Qing dynasty. We also discuss(More)
To investigate the possible pathways for transport of wheat germ agglutinin conjugated PEG-PLA nanoparticles (WGA-NP) into the brain after nasal administration. The nose-to-brain pathways were investigated using WGA-NP containing 6-coumarin (as a fluorescent marker) and 125I-labeled WGA-NP. Ex vivo imaging analysis was also employed to visualize the(More)
Phage display technology could provide a rapid means for the discovery of novel peptides. To find peptide ligands specific for the brain vascular receptors, we performed a modified phage display method. Phages were recovered from mice brain parenchyma after administrated with a random 7-mer peptide library intravenously. A longer circulation time was(More)
Vascular endothelial growth factor (VEGF) is one of the major cytokines secreted by activated hepatic stellate cells (HSCs). VEGF is involved in hepatic angiogenesis and plays an important role in the development of liver fibrosis. TNP-470, an angiogenic inhibitor, attenuates the development of rat liver fibrosis with reduced angiogenesis, as demonstrated(More)
This paper presents our research efforts on Chinese text-to-speech towards higher naturalness, the main results can be summarized as follows: 1. In the proposed TTS system the syllable-sized units were cut out from the real recorded speech, the synthetic speech was generated by concatenating these units back together. 2. The integration of units synthesized(More)