Qing-wen Shi

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Incorporation of curcumin and beta-ionone into one chemical entity led to identification of a novel antiandrogen with two bulky side chains, 6, which is a pure antagonist of the wild-type and the T877A, W741C, and H874Y mutated androgen receptors (AR), showing no cross-reactivity with progesterone receptor and low micromolar cytotoxicity in LNCaP, PCa-2b,(More)
3.1. Biosynthesis from Jatrophanes 4313 3.2. Biosynthesis from Lathyranes 4314 4. Biological Activity 4314 4.1. Antiproliferative Activity 4314 4.2. Cytotoxicity 4316 4.3. Effects on the Cell Division 4316 4.4. DNA-Damaging Activity 4316 4.5. Modulatority of Multidrug Resistance 4316 4.6. Tumor Promoting Activity 4318 4.7. Pro-Inflammatory Activity 4318(More)
Yi-Bing Wu,† Zhi-Yu Ni,† Qing-Wen Shi,*,† Mei Dong,‡ Hiromasa Kiyota,* Yu-Cheng Gu,†,∥ and Bin Cong*,‡ †School of Pharmaceutical Sciences, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province 050017, China ‡Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine,(More)
by Xi-Ping Zhanga), Man-Li Zhanga), Xiao-Huo Sua), Chang-Hong Huoa), Yu-Cheng Gub), and Qing-Wen Shi*a) a) Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China (e-mail: shiqingwen@hebmu.edu.cn) b) Syngenta Jealott s Hill International(More)
by Cong-Mei Caoa), Yong Penga), Qing-Wen Shib), and Pei-Gen Xiao*a) a) Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College, 151 Malianwa West Road, 100094, Beijing, P. R. China (phone: þ86-10-63011294; e-mail: xiaopg@public.bta.net.cn) b) Laboratory of Medicinal Natural Product Chemistry, School of(More)
A new paclitaxel derivative and two new 2(3-->20)-abeo-taxoids were isolated from a methanol extract of the seeds of Taxus mairei, and their structures were established as 1-deoxypaclitaxel (1), 7beta,10beta-diacetoxy-2alpha,5alpha,13alpha-trihydroxy-2(3-->20)-abeo-taxa-4(20),11-dien-9-one (2), and(More)
Eupatorium (family: Compositae), which comprises nearly 1200 species, is distributed throughout tropical America, Europe, Africa, and Asia. Up to now, the reported constituents from the genus Eupatorium involve flavonoids, terpenoids, pyrrolizidine alkaloids, phenylpropanoids, quinonoids, essential oils, and some others, altogether more than 300 compounds.(More)
Xylocarpus granatum K. D. Koenig, a marine mangrove plant distributed mainly along the seashore along the Indian Ocean and in Southeast Asia, is used in folk medicine in Southeast Asia for the treatment of diarrhea, cholera, and fever diseases such as malaria, and also as an antifeedant [1, 2]. Since the first limonoid, gedunin, was reported from this plant(More)