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To identify risk variants for lung cancer, we conducted a multistage genome-wide association study. In the discovery phase, we analyzed 315,450 tagging SNPs in 1,154 current and former (ever) smoking cases of European ancestry and 1,137 frequency-matched, ever-smoking controls from Houston, Texas. For replication, we evaluated the ten SNPs most(More)
The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research Collaboratory for Structural Bioinformatics (RCSB) has completely redesigned its resource for the distribution and query of 3D structure data. The re-engineered site is currently in public beta test at(More)
Skyline computation has many applications including multi-criteria decision making. In this paper, we study the problem of selecting k skyline points so that the number of points, which are dominated by at least one of these k skyline points, is maximized. We first present an efficient dynamic programming based exact algorithm in a 2d-space. Then, we show(More)
The Hippo (Hpo) signaling pathway governs cell growth, proliferation, and apoptosis by controlling key regulatory genes that execute these processes; however, the transcription factor of the pathway has remained elusive. Here we provide evidence that the TEAD/TEF family transcription factor Scalloped (Sd) acts together with the coactivator Yorkie (Yki) to(More)
Privacy is a serious concern when microdata need to be released for ad hoc analyses. The privacy goals of existing privacy protection approaches (e.g., k-anonymity and l-diversity) are suitable only for categorical sensitive attributes. Since applying them directly to numerical sensitive attributes (e.g., salary) may result in undesirable information(More)
Skyline has been proposed as an important operator for multi-criteria decision making, data mining and visualization, and userpreference queries. In this paper, we consider the problem of efficiently computing a Skycube, which consists of skylines of all possible non-empty subsets of a given set of dimensions. While existing skyline computation algorithms(More)
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced in the RPE of humans with GA, and that conditional ablation of Dicer1, but not seven other miRNA-processing enzymes, induces(More)
Computing becomes increasingly mobile and pervasive today; these changes imply that applications and services must be aware and adapt to highly dynamic environments. Today, building context-aware mobile services is a complex and timeconsuming task. In this paper, we present a Service-oriented Context-Aware Middleware (SOCAM) architecture for the building(More)
Private data often come in the form of associations between entities, such as customers and products bought from a pharmacy, which are naturally represented in the form of a large, sparse bipartite graph. As with tabular data, it is desirable to be able to publish anonymized versions of such data, to allow others to perform ad hoc analysis of aggregate(More)